Message in a Vesicle – Trans-kingdom Intercommunication
Vector-borne diseases cause over 700,000 deaths annually and represent 17% of all infectious illnesses worldwide. This public health menace highlights the importance of understanding how arthropod vectors, microbes, and their mammalian hosts interact. Currently, an emphasis of the scientific enterprise is at the vector–host interface where human pathogens are acquired and transmitted. At this spatial junction, arthropod effector molecules are secreted, enabling microbial pathogenesis and disease. Extracellular vesicles manipulate signaling networks by carrying proteins, lipids, carbohydrates and regulatory nucleic acids. Therefore, they are well positioned to aid in cell-to-cell communication and mediate molecular interactions.
This paper, Message in a vesicle – trans-kingdom intercommunication at the vector–host interface, is published in Journal of Cell Science.